Effect of paraoxonase genotype on paraoxonase activity and myocardial blood flow parameters. Effect of paraoxonase genotype on (a) paraoxonase activity, (b) response to cold pressor testing (ΔMBF, increase in myocardial blood flow), (c) rest MBF, (d) stress MBF, and (e) MFR. Note that the paraoxonase genotype only had an effect on paraoxonase plasma levels (p
< 0.0001), while there was no association with PET-measured indices of endothelium-dependent (ΔMBF) or -independent (stress MBF, MFR) vasomotion. Asterisks represent p
< 0.0001 vs. wild type [WT] + heterozygotes and p
< 0.0001 vs. homozygote-MM; dagger represents p = 0.083 vs. homozygotes-MM.