Effect of 6-OHDA on time profiles of the tissue radioactivity in brain and K
values. After the administration of [18F]FDOPA in rats. (a) Time-activity curves for the radioactivity in the contralateral striatum, ipsilateral striatum, and cerebellum. (b) K
i values in the bilateral striata of the different dosage groups (0 μg, n = 3; 7, 14, and 28 μg, n = 6). Asterisk (*): significant difference vs. the contralateral side; paired Student's t test; number sign (#): significant difference vs. the 0 μg group, one-way ANOVA followed by Dunnett's multiple comparison test. (c) K
i values expressed as the percentage ratio of the ipsilateral (right) to the contralateral (left) side for each 6-OHDA dose group.