Competition binding experiments using the NPY Y
receptor-expressing SK-N-MC cell line. All four tested compounds exhibit Y1 selectivity. While hPYY (solid circle) and 11 (solid diamond) show high-affinity displacements of 125I-hPYY the analogs 9 (solid square) and 10 (solid triangle) show lower affinity displacements of 125I-hPYY. Dose response curves of at least three independent experiments ± SEM are shown.