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EJNMMI Research
Figure 3 | EJNMMI Research

Figure 3

From: Novel dimeric DOTA-coupled peptidic Y1-receptor antagonists for targeting of neuropeptide Y receptor-expressing cancers

Figure 3

Competition binding experiments using the NPY Y 1 receptor-expressing SK-N-MC cell line. All four tested compounds exhibit Y1 selectivity. While hPYY (solid circle) and 11 (solid diamond) show high-affinity displacements of 125I-hPYY the analogs 9 (solid square) and 10 (solid triangle) show lower affinity displacements of 125I-hPYY. Dose response curves of at least three independent experiments ± SEM are shown.

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