Binding of TS1, an anti-keratin 8 antibody, in small-cell lung cancer after 177Lu-DOTA-Tyr3-octreotate treatment: a histological study in xenografted mice

EJNMMI Research

Table 1 Level of TS1 staining in the SCLC NCI-H69 and GOT1 midgut xenografts

Tumour	Treatment	Images	Mean value	Standard deviation
1	Untreated SCLC	29	27.8	15.3
2		19	8.3	6.2
3		33	8.5	6.2
4		23	11.5	6.3
5		41	12.0	7.8
6	1-day SCLC	17	39.0	7.4
7		6	10.8	4.4
8		14	25.8	6.7
9	5-day SCLC	20	60.8	5.7
10		19	62.4	9.8
11		18	27.7	4.6
12		17	24.4	6.1
13	12-day SCLC	40	58.1	10.0
14		13	20.4	3.0
15		22	36.2	9.8
16	20-day SCLC	17	41.4	17.9
17		16	39.4	15.7
18	Regrown SCLC	18	20.3	13.0
19		15	40.7	10.3
20		24	4.2	2.5
21	Untreated midgut	18	40.3	10.5
22		13	42.7	14.1
23		32	17.6	15.3
24	3-day midgut	21	49.3	10.7
25		35	60.8	10.6
26		14	52.7	17.3
27		13	60.7	9.5

The table illustrates the number of images analysed, mean value, and standard deviation per analysed tumour. The percentage (%) DAB-positive immunostaining for TS1 in the tumour xenografts was determined by use of ImageJ ImmunoRatio.