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Figure 2 | EJNMMI Research

Figure 2

From: Binding of TS1, an anti-keratin 8 antibody, in small-cell lung cancer after 177Lu-DOTA-Tyr3-octreotate treatment: a histological study in xenografted mice

Figure 2

Radiation effects on TS1 and Ki67 DAB-positive immunostaining. (a) Radiation effects on TS1 and Ki67 DAB-positive immunostaining in the SCLC NCI-H69 xenograft. The X-axis shows the numbers of days treated with177Lu-DOTA-Tyr3-octreotate. The Y-axis shows the percentage (%) mean value and standard deviation of DAB-positive immunostaining for TS1 and Ki67. Bars that are close together represent results from different sections of the same tumour group. TS1 (black bars), Ki67 (white bars). The 5- and 12-days treatment differ significantly from the untreated, p < 0.05, 5-days n = 4 and 12-days n = 3. (b) Radiation effects on TS1 and Ki67 DAB-positive immunostaining in the midgut GOT1 xenograft. The X-axis shows the numbers of days treated with177Lu-DOTA-Tyr3-octreotate. The Y-axis shows the percentage (%) mean value and standard deviation of DAB-positive immunostaining for TS1 and Ki67. Bars that are close together represent results from different sections of the same tumour group. TS1 (black bars), Ki67 (white bars). Three-days treatment differ significantly from the untreated, p < 0.05, n = 4.

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