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Figure 1 | EJNMMI Research

Figure 1

From: Binding of TS1, an anti-keratin 8 antibody, in small-cell lung cancer after 177Lu-DOTA-Tyr3-octreotate treatment: a histological study in xenografted mice

Figure 1

177 Lu-DOTA-Tyr3 -octreotate treatment effects on tumour cells visualised by staining with the anti-K8 antibody, TS1. (A) Untreated, midgut GOT1 xenograft; (B) Midgut GOT1 xenograft after 3 days of treatment; small necrotic areas are evident. (C) Untreated, SCLC NCI-H69 xenograft with viable, apoptotic, and necrotic cells; (D) SCLC NCI-H69 xenograft after 1 day of treatment; (E) SCLC NCI-H69 xenograft after 5 days of treatment; small necrotic areas are evident; and (F) SCLC NCI-H69 xenograft after 12 days of treatment. Red arrows indicate small necrotic areas, blue arrows point to apoptotic cells, and white or black arrows point to cells with multiple nuclei and micronuclei. Scale bar 100 μm.

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