Skip to main content

Advertisement

Table 3 Phosphatidylethanolamine-based radiolabelled molecular imaging probes

From: Transbilayer phospholipids molecular imaging

Molecular target Molecular probes AA MW (kDa) Affinity (M) Biological functions Isotopes Imaging techniques
PE duramycin 19 2 10-9 apoptosis
necrosis
99mTc a SPECT(CT)
PE ethanolamine
N'N-dimethyl ethanolamine
- - - ethanolamine metabolism (tumour proliferation) 14C b PET(CT)
PE c hypericin - 0.504 - necrosis 123I, 131I 99mTc SPECT(CT)
       64Cu d PET(CT)
  1. a HYNIC has been used as a bifunctional chelating agent for the radiolabelling of duramycin. b ethanolamine or N,N'-dimethylethanolamine labelled with 14C in preclinical in vitro research may be labelled with 11C or 18F for PET(CT) in vivo imaging. c 64Cu-bis-DOTA-hypericin has a selective binding affinity for PS and PE (ref.45); it may be hypothesised that 123I-, 131I- and 99mTc-labelled hypericin derivatives bind to PS and PE. d bis-DOTA has been used as a bifunctional chelating agent for the radiolabelling of hypericin. AA, amino acids; MW, molecular weight; PE, phosphatidylethanolamine; PET(CT), positron emission tomography (computed tomography); SPECT(CT), single-photon emission computed tomography (computed tomography).