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Figure 2 | EJNMMI Research

Figure 2

From: A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using microSPECT/CT or microPET/CT

Figure 2

Direct (saturation) radioligand binding assays. Direct (saturation) radioligand binding to SKBR-3 human breast cancer cells of (a) 111In-DOTA-trastuzumab Fab or (b) 64Cu-DOTA-trastuzumab Fab, in the absence (total binding; TB) or presence (non-specific binding; NSB) of excess (16 μM) unlabeled trastuzumab IgG. Specific binding (SB) was calculated by subtraction of NSB from TB. Curves were fitted to a 1-site receptor-binding model using Prism Ver. 4.0 software (GraphPad).

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