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Table 2 Summary of kinetic parameters

From: P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function

  K 1 (ml/cc/min) k 2 (1/min) K 1 /k 2
WT 1 0.054 0.190 0.28
WT 2 0.042 0.120 0.35
WT 3 0.027 0.059 0.46
KO 1 0.190 0.120 1.58
KO 2 0.230 0.095 2.42
KO 3 0.190 0.100 1.90
CYCLO 1 0.250 0.150 1.66
CYCLO 2 0.120 0.063 1.90
CYCLO 3 0.180 0.086 2.09
  1. Summary of kinetic parameters estimated from the one-tissue compartment model for 11C-desmethylloperamide for all mice studied, using the noninvasive (left heart ventricle-based) method to determine the input curve. CYCLO, wild-type mice pretreated with 50 mg/kg cyclosporine, 30 min before tracer injection; KO, knock-out mice; WT, wild-type mice.