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Table 2 Summary of kinetic parameters

From: P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function

 

K 1 (ml/cc/min)

k 2 (1/min)

K 1 /k 2

WT 1

0.054

0.190

0.28

WT 2

0.042

0.120

0.35

WT 3

0.027

0.059

0.46

KO 1

0.190

0.120

1.58

KO 2

0.230

0.095

2.42

KO 3

0.190

0.100

1.90

CYCLO 1

0.250

0.150

1.66

CYCLO 2

0.120

0.063

1.90

CYCLO 3

0.180

0.086

2.09

  1. Summary of kinetic parameters estimated from the one-tissue compartment model for 11C-desmethylloperamide for all mice studied, using the noninvasive (left heart ventricle-based) method to determine the input curve. CYCLO, wild-type mice pretreated with 50 mg/kg cyclosporine, 30 min before tracer injection; KO, knock-out mice; WT, wild-type mice.