|
K
1
(ml/cc/min) |
k
2
(1/min) |
K
1
/k
2
|
---|
WT 1 | 0.054 | 0.190 | 0.28 |
WT 2 | 0.042 | 0.120 | 0.35 |
WT 3 | 0.027 | 0.059 | 0.46 |
KO 1 | 0.190 | 0.120 | 1.58 |
KO 2 | 0.230 | 0.095 | 2.42 |
KO 3 | 0.190 | 0.100 | 1.90 |
CYCLO 1 | 0.250 | 0.150 | 1.66 |
CYCLO 2 | 0.120 | 0.063 | 1.90 |
CYCLO 3 | 0.180 | 0.086 | 2.09 |
- Summary of kinetic parameters estimated from the one-tissue compartment model for 11C-desmethylloperamide for all mice studied, using the noninvasive (left heart ventricle-based) method to determine the input curve. CYCLO, wild-type mice pretreated with 50 mg/kg cyclosporine, 30 min before tracer injection; KO, knock-out mice; WT, wild-type mice.