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Figure 5 | EJNMMI Research

Figure 5

From: P-glycoprotein at the blood-brain barrier: kinetic modeling of 11C-desmethylloperamide in mice using a 18F-FDG μPET scan to determine the input function

Figure 5

Sagittal images of mice after intravenous administration of 11 C-dLop. Sagittal images of knock-out mice (A), wild-type mice without cyclosporine pretreatment (B) and wild-type mice with cyclosporine pretreatment (50 mg/kg body weight, 30 min before tracer injection) (C), after intravenous administration of 20.0 ± 2.0 MBq of 11C-dLop. In each mice, the brains are indicated; the difference in tracer brain uptake between wild-type (no pretreatment), knock-out, and with cyclosporine-pretreated wild-type mice is clearly visible (color scale: black, lowest radioactivity uptake; red, highest radioactivity uptake).

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