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Table 1 Pharmacokinetic parameters of the VAP-1-targeting 68Ga-DOTA-peptides

From: Mini-PEG spacering of VAP-1-targeting 68Ga-DOTAVAP-P1 peptide improves PET imaging of inflammation

  68Ga-DOTAVAP-P1 68Ga-DOTAVAP-PEG-P1 P value
Elimination t 1/2 (min) 13.4 ± 1.8 28.0 ± 10.7 NS (0.079)
k el (1/min) 0.05 ± 0.01 0.02 ± 0.01 0.018
AUC (min*kBq/ml) 950 ± 170 2,400 ± 68 0.022
CL (ml/min) 0.017 ± 0.001 0.008 ± 0.002 0.006
  1. k el, elimination rate constant; AUC, area under curve; CL, clearance; NS, not significant.