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Table 1 In vitro analysis of panitumumab F(ab')2 conjugated with CHX-A"-DTPA.

From: In vitro and in vivo pre-clinical analysis of a F(ab')2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers

  Chelate:mAb ratio (molar excess)
  Panitumumab F(ab') 2 HuM195 F(ab') 2
Analysis 0 10× 20× 10×
IC50 (nM) 0.5 0.6 0.7 0.7 0
Specific activity (mCi/mg) - 1.9 14.8 2.9 9.4
Labeling yield (%) - 13.9 49.4 24.4 50
Chelate:protein ratio - 2.9 1.7 5.6 0.6
Percent binding - 59.5 59.4 54.7 1.8