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  1. Mitochondrial function plays a key role in regulating neurotransmission and may contribute to general intelligence. Mitochondrial complex I (MC-I) is the largest enzyme of the respiratory chain. Recently, it h...

    Authors: Ekaterina Shatalina, Thomas S. Whitehurst, Ellis Chika Onwordi, Barnabas J. Gilbert, Gaia Rizzo, Alex Whittington, Ayla Mansur, Hideo Tsukada, Tiago Reis Marques, Sridhar Natesan, Eugenii A. Rabiner, Matthew B. Wall and Oliver D. Howes
    Citation: EJNMMI Research 2024 14:41
    Content type: Original research Published on:

  2. The aim of this study was to assess the impact of the post-injection electrical seizure duration on the identification of the seizure onset zone (SOZ) in ictal brain perfusion SPECT in presurgical evaluation o...

    Authors: Amir Karimzadeh, Kian Baradaran-Salimi, Berthold Voges, Ivayla Apostolova, Thomas Sauvigny, Michael Lanz, Susanne Klutmann, Stefan Stodieck, Philipp T. Meyer and Ralph Buchert
    Citation: EJNMMI Research 2024 14:40
    Content type: Original research Published on:

  3. Kinetic modeling of 18F-florbetaben provides important quantification of brain amyloid deposition in research and clinical settings but its use is limited by the requirement of arterial blood data for quantitativ...

    Authors: Emily Nicole Holy, Elizabeth Li, Anjan Bhattarai, Evan Fletcher, Evelyn R. Alfaro, Danielle J. Harvey, Benjamin A. Spencer, Simon R. Cherry, Charles S. DeCarli and Audrey P. Fan
    Citation: EJNMMI Research 2024 14:39
    Content type: Original research Published on:

  5. A new generation of radiolabeled minigastrin analogs delivers low radiation doses to kidneys and are considered relatively stable due to less enzymatic degradation. Nevertheless, relatively low tumor radiation...

    Authors: Christof Rottenburger, Michael Hentschel, Markus Fürstner, Lisa McDougall, Danijela Kottoros, Felix Kaul, Rosalba Mansi, Melpomeni Fani, A. Hans Vija, Roger Schibli, Susanne Geistlich, Martin Behe, Emanuel R. Christ and Damian Wild
    Citation: EJNMMI Research 2024 14:37
    Content type: Original research Published on:

  6. Liver uptake in [68Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [177Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [68Ga]Ga-PSMA...

    Authors: Cristina E. Popescu, Boya Zhang, Thomas Sartoretti, Noel Spielhofer, Stephan Skawran, Jakob Heimer, Michael Messerli, Alexander Sauter, Martin W. Huellner, Philipp A. Kaufmann, Irene A. Burger and Alexander Maurer
    Citation: EJNMMI Research 2024 14:36
    Content type: Original research Published on:

  8. In juvenile systemic lupus erythematosus (j-SLE) with neuropsychiatric (NP) symptoms, there is a lack of diagnostic biomarkers. Thus, we study whether PET-FDG may identify any metabolic dysfunction in j-NPSLE.

    Authors: Sebastian Rodrigo, Stefania Costi, Pierre Ellul, Melodie Aubart, Nathalie Boddaert, Stephane Auvin, Monique Elmaleh, Alexandra Ntorkou, Brigitte Bader-Meunier, Vincent Lebon, Isabelle Melki and Catherine Chiron
    Citation: EJNMMI Research 2024 14:34
    Content type: Original research Published on:

  9. Accurate measurement of the arterial input function (AIF) is crucial for parametric PET studies, but the AIF is commonly derived from invasive arterial blood sampling. It is possible to use an image-derived in...

    Authors: Hamed Moradi, Rajat Vashistha, Soumen Ghosh, Kieran O’Brien, Amanda Hammond, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:33
    Content type: Original research Published on:

  10. Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinic...

    Authors: Mark Muzi, Lanell M. Peterson, Jennifer M. Specht, Daniel S. Hippe, Alena Novakova-Jiresova, Jean H. Lee, Brenda F. Kurland, David A. Mankoff, Nancy Obuchowski, Hannah M. Linden and Paul E. Kinahan
    Citation: EJNMMI Research 2024 14:32
    Content type: Original research Published on:

  11. Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variab...

    Authors: Mette Abildgaard Pedersen, André H. Dias, Karin Hjorthaug, Lars C. Gormsen, Joan Fledelius, Anna Lyhne Johnsson, Signe Borgquist, Trine Tramm, Ole Lajord Munk and Mikkel Holm Vendelbo
    Citation: EJNMMI Research 2024 14:31
    Content type: Original research Published on:

  12. We designed and synthesized a novel bisphosphonate radiopharmaceutical (68 Ga- or 177Lu-labeled DOTA-ibandronate [68 Ga/177Lu-DOTA-IBA]) for the targeted diagnosis and treatment of bone metastases. The biodistrib...

    Authors: Hongmei Li, Wenjie Pei, Xiqun Yang, Gengcuo Qu, Qingchu Hua, Lin Liu, Yudi Wang, Tingting Xu and Yue Chen
    Citation: EJNMMI Research 2024 14:30
    Content type: Original research Published on:

  13. Cancer stem cells play an important role in driving tumor growth and treatment resistance, which makes them a promising therapeutic target to prevent cancer recurrence. Emerging cance...

    Authors: Kevin Wyszatko, Nancy Janzen, Luis Rafael Silva, Luke Kwon, Teesha Komal, Manuela Ventura, Chitra Venugopal, Sheila K. Singh, John F. Valliant and Saman Sadeghi
    Citation: EJNMMI Research 2024 14:29
    Content type: Original research Published on:

  14. Neuropsychiatric sequelae of COVID-19 have been widely documented in patients with severe neurological symptoms during the chronic or subacute phase of the disease. However, it remains unclear whether subclini...

    Authors: Stephan P. M. Souza, Nicoli Colet, Mariana Fujiwara, Alins P. Fernandes, Natalia Tobar, Sergio S. J. Dertkigil, Maria Emilia S. Takahashi, Bárbara J. Amorim, Lucas S. Silva, Clarissa L. Yasuda, Fernando Cendes, Thiago F. de Souza, Juliano T. Rodrigues, Denise E. Zantut-Wittmann and Celso Dario Ramos
    Citation: EJNMMI Research 2024 14:28
    Content type: Original research Published on:

  15. Meta-analysis show the diagnostic performance of cardiac dedicated multi-pinhole cadmium-zinc-telluride myocardial perfusion imaging (MPI) with a sensibility around 0.9 and a specificity around 0.7. The aim of...

    Authors: Fabien Vauchot, Julien Dubois and Aurélie Bourdon
    Citation: EJNMMI Research 2024 14:27
    Content type: Original research Published on:

  16. Glioblastoma is an extremely aggressive malignant tumor with a very poor prognosis. Due to the increased proliferation rate of glioblastoma, there is the development of hypoxic regions, characterized by an inc...

    Authors: Catarina I. G. Pinto, André D. M. Branco, Sara Bucar, Alexandra Fonseca, Antero J. Abrunhosa, Cláudia L. da Silva, Joana F. Guerreiro and Filipa Mendes
    Citation: EJNMMI Research 2024 14:26
    Content type: Original research Published on:

  17. P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [11C]SMW139 is the most recently developed radiotracer to image P2X7 receptor. The a...

    Authors: Obada M. Alzghool, Richard Aarnio, Jatta S. Helin, Saara Wahlroos, Thomas Keller, Markus Matilainen, Junel Solis, Jonathan J. Danon, Michael Kassiou, Anniina Snellman, Olof Solin, Juha O. Rinne and Merja Haaparanta-Solin
    Citation: EJNMMI Research 2024 14:25
    Content type: Original research Published on:

  18. Correct classification of estrogen receptor (ER) status is essential for prognosis and treatment planning in patients with breast cancer (BC). Therefore, it is recommended to sample tumor tissue from an access...

    Authors: Mette A. Pedersen, Ole L. Munk, André H. Dias, Johanne H. Steffensen, Anders L. Møller, Anna Lyhne Johnsson, Kim Vang Hansen, Dirk Bender, Steen Jakobsen, Morten Busk, Lars C. Gormsen, Trine Tramm, Signe Borgquist and Mikkel H. Vendelbo
    Citation: EJNMMI Research 2024 14:24
    Content type: Original research Published on:

  19. We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in t...

    Authors: Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester and Thomas Günther
    Citation: EJNMMI Research 2024 14:23
    Content type: Original research Published on:

  20. Cisplatin- based chemoradiotherapy is a crucial pillar in the treatment of HNSCC. The use of cisplatin comes with high toxicity rates as 35% of patients cannot sustain the planned dose while response is unpred...

    Authors: Reinout H. de Roest, Marijke Stigter van Walsum, Karlijn van der Schilden and Ruud H. Brakenhoff
    Citation: EJNMMI Research 2024 14:22
    Content type: Original research Published on:

  21. 18F-FDG positron emission tomography (PET) plays a crucial part in the evaluation for pediatric epileptic patients prior to therapy. Short-term scanning holds significant importance, especially for pediatrics ep....

    Authors: Min Li, Xiao Cui, Huixin Yue, Chao Ma, Kun Li, Leiying Chai, Min Ge, Hui Li, Yee Ling Ng, Yun Zhou, Jianguo Shi, Yanhua Duan and Zhaoping Cheng
    Citation: EJNMMI Research 2024 14:21
    Content type: Original research Published on:

  22. In the present study, we aimed to investigate the role of baseline (B), interim (I) and end-of-treatment (Eot) 18F-FDG PET/CT in assessing the prognosis of diffuse large B cell lymphoma (DLBCL), so as to identify...

    Authors: Wenyu Zhao, Xiaodong Wu, Shuo Huang, Hui Wang and Hongliang Fu
    Citation: EJNMMI Research 2024 14:20
    Content type: Original research Published on:

  23. Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, ther...

    Authors: Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier and Albert D. Windhorst
    Citation: EJNMMI Research 2024 14:19
    Content type: Original research Published on:

  24. Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irre...

    Authors: Jessica E. Wijngaarden, Yvonne W. S. Jauw, Gerben J. C. Zwezerijnen, Berlinda J. de Wit-van der Veen, Daniëlle J. Vugts, Josée M. Zijlstra, Guus A. M. S. van Dongen, Ronald Boellaard, C. Willemien Menke-van der Houven van Oordt and Marc C. Huisman
    Citation: EJNMMI Research 2024 14:18
    Content type: Original research Published on:

  25. Endometriosis is characterized by the ectopic occurrence of endometrial tissue. Though considered benign, endometriotic lesions possess tumor-like properties such as tissue invasion and remodeling of the extra...

    Authors: Belinda Trachsel, Stefan Imobersteg, Giulia Valpreda, Gad Singer, Regula Grabherr, Mark Ormos, Irene A. Burger, Rahel A. Kubik-Huch, Roger Schibli, Viola Vogel and Martin Béhé
    Citation: EJNMMI Research 2024 14:17
    Content type: Original research Published on:

  26. The prevalence of ischemia with non-obstructive coronary artery disease (INOCA) is substantial, but its risk stratification has been suboptimal. Resting SPECT myocardial perfusion imaging (MPI) could provide u...

    Authors: Yuting Zhao, Yingqi Hu, Yuanyuan Li, Yanhui Wang, Yuxin Xiao, Li Xu, Tailin Ren, Qiuyan Wu, Ruonan Wang, Zhifang Wu, Sijin Li and Ping Wu
    Citation: EJNMMI Research 2024 14:16
    Content type: Original research Published on:

  27. Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This resea...

    Authors: Yang Liu, Li Xia, Haiyang Li, Ping Cai, Sufan Tang, Yue Feng, Guangfu Liu, Yue Chen, Nan Liu, Wei Zhang and Zhijun Zhou
    Citation: EJNMMI Research 2024 14:15
    Content type: Original research Published on:

  28. Previous studies have demonstrated that delayed [68 Ga]Ga-PSMA PET/CT imaging improves lesion detection compared to early [68 Ga]Ga-PSMA PET/CT in patients with prostate cancer. However, the sole use of delayed [

    Authors: Xiaofeng Yu, Lian Xu, Gang Huang, Jianjun Liu, Ruohua Chen and Yumei Chen
    Citation: EJNMMI Research 2024 14:14
    Content type: Original research Published on:

  29. Peptide receptor radionuclide therapy is effective in treating neuroendocrine tumours, but treatment may be limited by kidney and bone marrow toxicity. In this work, the absorbed dose burden to the bone marrow...

    Authors: Märta Persson, Cecilia Hindorf, Oscar Ardenfors, Martin Larsson and Joachim N. Nilsson
    Citation: EJNMMI Research 2024 14:13
    Content type: Original research Published on:

  31. [15O]H2O PET/CT allows noninvasive quantification of tissue perfusion and can potentially play a future role in the diagnosis and treatment of peripheral artery disease. We aimed to evaluate the reliability of dy...

    Authors: Nana Louise Christensen, Jens Sørensen, Kirsten Bouchelouche, Michael Alle Madsen, Christian Selmer Buhl and Lars Poulsen Tolbod
    Citation: EJNMMI Research 2024 14:11
    Content type: Original research Published on:

  32. The indirect method for generating parametric images in positron emission tomography (PET) involves the acquisition and reconstruction of dynamic images and temporal modelling of tissue activity given a measur...

    Authors: Rajat Vashistha, Hamed Moradi, Amanda Hammond, Kieran O’Brien, Axel Rominger, Hasan Sari, Kuangyu Shi, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:10
    Content type: Original research Published on:

  33. Developing biomarkers for early stage AD patients is crucial. Glucose metabolism measured by 18F-FDG PET is the most common biomarker for evaluating cellular energy metabolism to diagnose AD. Arterial spin labeli...

    Authors: Sheng Bi, Shaozhen Yan, Zhigeng Chen, Bixiao Cui, Yi Shan, Hongwei Yang, Zhigang Qi, Zhilian Zhao, Ying Han and Jie Lu
    Citation: EJNMMI Research 2024 14:9
    Content type: Original research Published on:

  34. The increased expression of the nicotinic acetylcholine receptor (nAChR) in muscle denervation is thought to be associated with electrophysiological acetylcholine supersensitivity after nerve injury. Hence, we...

    Authors: Yong-il Kim, Seung Hak Lee, Jin Hwa Jung, Seog-Young Kim, Nare Ko, Sang Ju Lee, Seung Jun Oh, Jin-Sook Ryu, Dabin Ko, Won Kim and Kyunggon Kim
    Citation: EJNMMI Research 2024 14:8
    Content type: Original research Published on:

  35. Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targetin...

    Authors: Victoria J. M. Reid, Wesley K. X. McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A. Marti, Dominic Kurian, Thomas M. Wishart, Christophe Lucatelli, Dan Peters, Gillian A. Gray, Andrew H. Baker, David E. Newby, Patrick W. F. Hadoke, Adriana A. S. Tavares…
    Citation: EJNMMI Research 2024 14:7
    Content type: Original research Published on:

  36. 68Ga-PSMA-11 positron emission tomography enables the detection of primary, recurrent, and metastatic prostate cancer. Regional radiopharmaceutical uptake is generally evaluated in static images and quantified a....

    Authors: Nathaniel J. Smith, Mark A. Green, Clinton D. Bahler, Mark Tann, Wendy Territo, Anne M. Smith and Gary D. Hutchins
    Citation: EJNMMI Research 2024 14:6
    Content type: Original research Published on:

  37. Immune checkpoint inhibitors (ICIs) have made significant progress in oncotherapy improving survival of patients. However, the benefits are limited to only a small subgroup of patients who could achieve durabl...

    Authors: Xiaoyu Fan, Hans W. Nijman, Marco de Bruyn and Philip H. Elsinga
    Citation: EJNMMI Research 2024 14:5
    Content type: Review Published on:

  38. The influence of anaesthetic depth and the potential influence of different anaesthetic beds and thus different handling procedures were investigated in 86 severe combined immunodeficient (SCID) mice using sem...

    Authors: Fabian Schmitz-Peiffer, Mathias Lukas, Ajay-Mohan Mohan, Jakob Albrecht, Jörg R. Aschenbach, Winfried Brenner and Nicola Beindorff
    Citation: EJNMMI Research 2024 14:4
    Content type: Original research Published on:

  40. The identification of biomarkers predicting the treatment response of rheumatoid arthritis (RA) is important. [68 Ga]Ga-FAPI-04 showed markedly increased uptake in the joints of patients with RA. The purpose of t...

    Authors: Qingqing Pan, Huaxia Yang, Ziyue Zhou, Min Li, Xu Jiang, Fang Li, Yaping Luo and Mengtao Li
    Citation: EJNMMI Research 2024 14:2
    Content type: Original research Published on:

  41. In parametric PET, kinetic parameters are extracted from dynamic PET images. It is not commonly used in clinical practice because of long scan times and the requirement for an arterial input function (AIF). To...

    Authors: Hamed Moradi, Rajat Vashistha, Kieran O’Brien, Amanda Hammond, Viktor Vegh and David Reutens
    Citation: EJNMMI Research 2024 14:1
    Content type: Original research Published on:

  42. The diagnostic accuracy of [18F]-fluorodeoxyglucose ([18F]-FDG) positron emission tomography imaging in accurately identifying thyroid lesions is limited, primarily due to the physiological uptake of normal head ...

    Authors: Yuhua Wang, Ye Liu, Huixia Geng and Wanchun Zhang
    Citation: EJNMMI Research 2023 13:109
    Content type: Review Published on:

  43. Both [18F]FDOPA (FDOPA) and [68Ga]DOTATOC PET/CT (DOTATOC) are widely used for detection of pheochromocytomas/paraganglioma (PPGL). However, direct comparisons of the performance of the two tracers are only avail...

    Authors: Peter Iversen, Stine Kramer, Andreas Ebbehoj, Esben Søndergaard, Kirstine Stochholm, Per Løgstrup Poulsen and Karin Hjorthaug
    Citation: EJNMMI Research 2023 13:108
    Content type: Original research Published on:

  44. Beta-cell replacement methods such as transplantation of isolated donor islets have been proposed as a curative treatment of type 1 diabetes, but widespread application is challenging due to shortages of donor...

    Authors: Pierre Cheung, Julia Thorngren, Bo Zhang, Svitlana Vasylovska, Francesco Lechi, Jonas Persson, Stefan Ståhl, John Löfblom, Olle Korsgren, Jonas Eriksson, Joey Lau and Olof Eriksson
    Citation: EJNMMI Research 2023 13:107
    Content type: Original research Published on:

  45. The apolipoprotein E-deficient (apoE−/−) mouse is a well-established model for studying atherosclerosis. However, its small size limits its use in longitudinal positron emission tomography (PET) imaging studies. ...

    Authors: Jürgen W. A. Sijbesma, Aren van Waarde, Sebastiaan Kristensen, Ilse Kion, Uwe J. F. Tietge, Jan-Luuk Hillebrands, Marian L. C. Bulthuis, Hendrik Buikema, Dalibor Nakladal, Marit Westerterp, Fan Liu, Hendrikus H. Boersma, Rudi A. J. O. Dierckx and Riemer H. J. A. Slart
    Citation: EJNMMI Research 2023 13:106
    Content type: Original research Published on:

  46. This study aimed to assess whether a combined model incorporating radiomic and depth features extracted from PET/CT can predict disease-free survival (DFS) in patients who failed to achieve pathologic complete...

    Authors: Xingxing Zheng, Yuhong Huang, Yingyi Lin, Teng Zhu, Jiachen Zou, Shuxia Wang and Kun Wang
    Citation: EJNMMI Research 2023 13:105
    Content type: Original research Published on:

  47. Until recently, quantitation of the net influx of 2-[18F]fluorodeoxyglucose (FDG) to brain (Ki) and the cerebrometabolic rate for glucose (CMRglc) required serial arterial blood sampling in conjunction with dynam...

    Authors: Paul Cumming, André H. Dias, Lars C. Gormsen, Allan K. Hansen, Ian Alberts, Axel Rominger, Ole L. Munk and Hasan Sari
    Citation: EJNMMI Research 2023 13:104
    Content type: Original research Published on:

  48. Metabolic imaging is routinely used to demonstrate aortitis in patients with giant-cell arteritis. We aimed to investigate the preclinical model of aortitis in BALB/c IL1rn−/− mice using [18F]fluorodeoxyglucose (...

    Authors: Samuel Deshayes, Caroline Baugé, Pierre-Antoine Dupont, Christophe Simard, Hanan Rida, Hubert de Boysson, Alain Manrique and Achille Aouba
    Citation: EJNMMI Research 2023 13:103
    Content type: Original research Published on:

  49. Brain metastases (BM) are the most frequent malignant brain tumors. The aim of this study was to characterize the tumor microenvironment (TME) of BM and particularly hypoxia and redox state, known to play a ro...

    Authors: Jade Fantin, Jérôme Toutain, Elodie A. Pérès, Benoit Bernay, Sarina Maya Mehani, Charly Helaine, Mickael Bourgeois, Carole Brunaud, Laurent Chazalviel, Julien Pontin, Aurélien Corroyer-Dulmont, Samuel Valable, Michel Cherel and Myriam Bernaudin
    Citation: EJNMMI Research 2023 13:102
    Content type: Original research Published on:

  50. Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres a...

    Authors: Arnaud Dieudonné, Stéphanie Becker, Miguel Soares, Claire Hollenbeck, Marie-Christine De Goltstein, Pierre Vera and Robin Santus
    Citation: EJNMMI Research 2023 13:101
    Content type: Original research Published on:

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