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  1. Preliminary Research

    Use of a digital phantom developed by QIBA for harmonizing SUVs obtained from the state-of-the-art SPECT/CT systems: a multicenter study

    Although quantitative analysis using standardized uptake value (SUV) becomes realistic in clinical single-photon emission computed tomography/computed tomography (SPECT/CT) imaging, reconstruction parameter se...

    Tadaki Nakahara, Hiromitsu Daisaki, Yasushi Yamamoto, Takashi Iimori, Kazuyuki Miyagawa, Tomoya Okamoto, Yoshiki Owaki, Nobuhiro Yada, Koichi Sawada, Ryotaro Tokorodani and Masahiro Jinzaki

    EJNMMI Research 2017 7:53

    Published on: 20 June 2017

  2. Original research

    PET/CT scanning with 3D acquisition is feasible for quantifying myocardial blood flow when diagnosing coronary artery disease

    The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). 15O-water positron emission tomogra...

    Osamu Manabe, Masanao Naya, Tadao Aikawa, Masahiko Obara, Keiichi Magota, Markus Kroenke, Noriko Oyama-Manabe, Kenji Hirata, Daiki Shinyama, Chietsugu Katoh and Nagara Tamaki

    EJNMMI Research 2017 7:52

    Published on: 5 June 2017

  3. Short communication

    Response assessment with the CXCR4-directed positron emission tomography tracer [68Ga]Pentixafor in a patient with extranodal marginal zone lymphoma of the orbital cavities

    CXCR4 belongs to the family of chemokine receptors. Together with its sole known ligand CXCL12 (SDF-1alpha), it has a pivotal role during organogenesis and for homing of hematopoietic stem cells. CXCR4 is over...

    Peter Herhaus, Stefan Habringer, Tibor Vag, Katja Steiger, Julia Slotta-Huspenina, Carlos Gerngroß, Benedikt Wiestler, Hans-Jürgen Wester, Markus Schwaiger and Ulrich Keller

    EJNMMI Research 2017 7:51

    Published on: 2 June 2017

  4. Original research

    Clinical value of fluorine-18α-methyltyrosine PET in patients with gliomas: comparison with fluorine-18 fluorodeoxyglucose PET

    We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine (18F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeo...

    Keishi Horiguchi, Masahiko Tosaka, Tetsuya Higuchi, Yukiko Arisaka, Kenichi Sugawara, Junko Hirato, Hideaki Yokoo, Yoshito Tsushima and Yuhei Yoshimoto

    EJNMMI Research 2017 7:50

    Published on: 31 May 2017

  5. Original research

    Towards standardization of 18F-FET PET imaging: do we need a consistent method of background activity assessment?

    PET with O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) has reached increasing clinical significance for patients with brain neoplasms. For quantification of standard PET-derived parameters such as the tumor-to-backg...

    Marcus Unterrainer, Franziska Vettermann, Matthias Brendel, Adrien Holzgreve, Michael Lifschitz, Matthias Zähringer, Bogdana Suchorska, Vera Wenter, Ben M. Illigens, Peter Bartenstein and Nathalie L. Albert

    EJNMMI Research 2017 7:48

    Published on: 30 May 2017

  6. Original research

    Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab

    The ability to image vascular endothelial growth factor (VEGF) could enable prospective, non-invasive monitoring of patients receiving anti-angiogenic therapy. This study investigates the specificity and pharm...

    Neel Patel, Sarah Able, Danny Allen, Emmanouil Fokas, Bart Cornelissen, Fergus V. Gleeson, Adrian L. Harris and Katherine A. Vallis

    EJNMMI Research 2017 7:49

    Published on: 30 May 2017

  7. Original research

    Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

    An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fl...

    Christopher Coello, Marie Fisk, Divya Mohan, Frederick J. Wilson, Andrew P. Brown, Michael I. Polkey, Ian Wilkinson, Ruth Tal-Singer, Philip S. Murphy, Joseph Cheriyan and Roger N. Gunn

    EJNMMI Research 2017 7:47

    Published on: 25 May 2017

  8. Original research

    Optimization of diagnostic performance for differentiation of recurrence from radiation necrosis in patients with metastatic brain tumors using tumor volume-corrected 11C-methionine uptake

    Tumor to normal tissue ratio (T/N ratio) on 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors. We investigated whether T/N ratio cutoff values corr...

    Tae-Young Jung, In-Young Kim, Sa-Hoe Lim, Ki Seong Park, Dong-Yeon Kim, Shin Jung, Kyung-Sub Moon, Woo-Youl Jang, Sae-Ryung Kang, Sang-Geon Cho, Jung-Joon Min, Hee-Seung Bom and Seong Young Kwon

    EJNMMI Research 2017 7:45

    Published on: 23 May 2017

  9. Original Research

    Clinical and imaging-based prognostic factors in radioembolisation of liver metastases from colorectal cancer: a retrospective exploratory analysis

    The aim of this study was to investigate the relationship between absorbed dose and response of colorectal cancer liver metastases treated with [90Y]-resin microspheres and to explore possible clinical and imagin...

    Kathy P. Willowson, Aimee R. Hayes, David L. H. Chan, Michael Tapner, Elizabeth J. Bernard, Richard Maher, Nick Pavlakis, Stephen J. Clarke and Dale L. Bailey

    EJNMMI Research 2017 7:46

    Published on: 23 May 2017

  10. Original research

    First in-human radiation dosimetry of 68Ga-NODAGA-RGDyK

    Integrin-targeting radiopharmaceuticals have potential broad applications, spanning from cancer theranostics to cardiovascular diseases. We have previously reported preclinical dosimetry results of 68Ga-NODAGA-RG...

    Silvano Gnesin, Periklis Mitsakis, Francesco Cicone, Emmanuel Deshayes, Vincent Dunet, Augusto F. Gallino, Marek Kosinski, Sébastien Baechler, Franz Buchegger, David Viertl and John O. Prior

    EJNMMI Research 2017 7:43

    Published on: 18 May 2017

  11. Original research

    Repeatability of quantitative parameters of 18F-fluoride PET/CT and biochemical tumour and specific bone remodelling markers in prostate cancer bone metastases

    18F-fluoride PET/CT exhibits high sensitivity to delineate and measure the extent of bone metastatic disease in patients with prostate cancer. 18F-fluoride PET/CT could potentially replace traditional bone sci...

    Cecilia Wassberg, Mark Lubberink, Jens Sörensen and Silvia Johansson

    EJNMMI Research 2017 7:42

    Published on: 15 May 2017

  12. Original research

    Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using 111In-tilmanocept

    Atherosclerotic plaque phenotypes are classified based on the extent of macrophage infiltration into the lesions, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The ma...

    Zohreh Varasteh, Fabien Hyafil, Nadège Anizan, Devy Diallo, Rachida Aid-Launais, Sarajo Mohanta, Yuanfang Li, Miriam Braeuer, Katja Steiger, Jonathan Vigne, Zhengtao Qin, Stephan G. Nekolla, Jean-Etienne Fabre, Yvonne Döring, Dominique Le Guludec, Andreas Habenicht…

    EJNMMI Research 2017 7:40

    Published on: 3 May 2017

  13. Original research

    Carotid atherosclerotic plaques standardised uptake values: software challenges and reproducibility

    Positron emission tomography–computed tomography (PET-CT) carotid standardised uptake values (SUV) of 18F-fluorodeoxyglucose (18FDG) have been proposed as an inflammatory biomarker for determining cerebrovascular...

    Nicola Giannotti, Martin J. O’Connell, Shane J. Foley, Peter J. Kelly and Jonathan P. McNulty

    EJNMMI Research 2017 7:39

    Published on: 28 April 2017

  14. Original research

    Therapeutic efficacy of α-radioimmunotherapy with different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model

    The aim of this study was to compare the therapeutic efficacy of two different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model. Sixty female BALB/c (nu/nu) mice were inocu...

    Anna Gustafsson-Lutz, Tom Bäck, Emma Aneheim, Ragnar Hultborn, Stig Palm, Lars Jacobsson, Alfred Morgenstern, Frank Bruchertseifer, Per Albertsson and Sture Lindegren

    EJNMMI Research 2017 7:38

    Published on: 24 April 2017

  15. Original research

    Effective dose estimation for oncological and neurological PET/CT procedures

    The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety of PET radiopharmaceutical compounds.

    Josep M. Martí-Climent, Elena Prieto, Verónica Morán, Lidia Sancho, Macarena Rodríguez-Fraile, Javier Arbizu, María J. García-Velloso and José A. Richter

    EJNMMI Research 2017 7:37

    Published on: 24 April 2017

  16. Original research

    Partial volume correction of brain PET studies using iterative deconvolution in combination with HYPR denoising

    Accurate quantification of PET studies depends on the spatial resolution of the PET data. The commonly limited PET resolution results in partial volume effects (PVE). Iterative deconvolution methods (IDM) have...

    Sandeep S. V. Golla, Mark Lubberink, Bart N. M. van Berckel, Adriaan A. Lammertsma and Ronald Boellaard

    EJNMMI Research 2017 7:36

    Published on: 21 April 2017

  17. Original research

    The effect of post-injection 18F-FDG PET scanning time on texture analysis of peripheral nerve sheath tumours in neurofibromatosis-1

    Texture features are being increasingly evaluated in 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as adjunctive imaging biomarkers in a number of different cancers. Whilst studies have report...

    Eitan Lovat, Musib Siddique, Vicky Goh, Rosalie E. Ferner, Gary J. R. Cook and Victoria S. Warbey

    EJNMMI Research 2017 7:35

    Published on: 20 April 2017

  18. Original research

    High-throughput high-volume nuclear imaging for preclinical in vivo compound screening§

    Preclinical single-photon emission computed tomography (SPECT)/CT imaging studies are hampered by low throughput, hence are found typically within small volume feasibility studies. Here, imaging and image anal...

    Sven Macholl, Ciara M. Finucane, Jacob Hesterman, Stephen J. Mather, Rachel Pauplis, Deirdre Scully, Jane K. Sosabowski and Erwan Jouannot

    EJNMMI Research 2017 7:33

    Published on: 7 April 2017

  19. Original research

    Tracking dendritic cell migration into lymph nodes by using a novel PET probe 18F-tetrafluoroborate for sodium/iodide symporter

    Recently, 18F-tetrafluoroborate (TFB) was used as a substrate for the human sodium/iodide symporter (hNIS) reporter gene. This study evaluated the feasibility of performing molecular-genetic imaging by using the ...

    Sang Bong Lee, Ho Won Lee, Hongje Lee, Yong Hyun Jeon, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee and Shin Young Jeong

    EJNMMI Research 2017 7:32

    Published on: 4 April 2017

  20. Original research

    Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

    The P2X7 receptor has been shown to play a fundamental role in the initiation and sustenance of the inflammatory cascade. The development of a novel fluorine-18 PET tracer superior and with a longer half-life ...

    Enrico Raffaele Fantoni, Diego Dal Ben, Simonetta Falzoni, Francesco Di Virgilio, Simon Lovestone and Antony Gee

    EJNMMI Research 2017 7:31

    Published on: 4 April 2017

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