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  1. Original research

    The extent to which standardized uptake values reflect FDG phosphorylation in the liver and spleen as functions of time after injection of 18F-fluorodeoxyglucose

    In FDG PET/CT, standardized uptake value (SUV) is used to measure metabolic activity but detects un-phosphorylated FDG as well as phosphorylated FDG (FDG6P). Our aim was to determine the proportions of intrahe...

    Georgia Keramida, Constantinos D. Anagnostopoulos and A. Michael Peters

    EJNMMI Research 2017 7:13

    Published on: 7 February 2017

  2. Original research

    Impact of PET acquisition durations on image quality and lesion detectability in whole-body 68Ga-PSMA PET-MRI

    While 68Ga-PSMA PET-MRI might be superior to PET-CT with regard to soft tissue assessment in prostate cancer evaluation, it is also known to potentially introduce additional PET image artefacts. Therefore, the im...

    Benjamin Noto, Florian Büther, Katharina Auf der Springe, Nemanja Avramovic, Walter Heindel, Michael Schäfers, Thomas Allkemper and Lars Stegger

    EJNMMI Research 2017 7:12

    Published on: 6 February 2017

  3. Original research

    Comparison of machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer from 18F-FDG PET/CT images

    This study aimed to compare one state-of-the-art deep learning method and four classical machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer (NSCLC) from 18F-F...

    Hongkai Wang, Zongwei Zhou, Yingci Li, Zhonghua Chen, Peiou Lu, Wenzhi Wang, Wanyu Liu and Lijuan Yu

    EJNMMI Research 2017 7:11

    Published on: 28 January 2017

  4. Original research

    The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [123I]FP-CIT SPECT imaging

    The use of a normal database for [123I]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretatio...

    John C. Dickson, Livia Tossici-Bolt, Terez Sera, Jan Booij, Morten Ziebell, Silvia Morbelli, Susanne Assenbaum-Nan, Thierry Vander Borght, Marco Pagani, Ozlem L. Kapucu, Swen Hesse, Koen Van Laere, Jacques Darcourt, Andrea Varrone and Klaus Tatsch

    EJNMMI Research 2017 7:10

    Published on: 24 January 2017

  5. Original research

    44Sc-PSMA-617 for radiotheragnostics in tandem with 177Lu-PSMA-617—preclinical investigations in comparison with 68Ga-PSMA-11 and 68Ga-PSMA-617

    The targeting of the prostate-specific membrane antigen (PSMA) is of particular interest for radiotheragnostic purposes of prostate cancer. Radiolabeled PSMA-617, a 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-te...

    Christoph A. Umbricht, Martina Benešová, Raffaella M. Schmid, Andreas Türler, Roger Schibli, Nicholas P. van der Meulen and Cristina Müller

    EJNMMI Research 2017 7:9

    Published on: 19 January 2017

  6. Original research

    A comparison of FLT to FDG PET/CT in the early assessment of chemotherapy response in stages IB–IIIA resectable NSCLC

    The aim of this study was to compare the percentage change in 18F-fluorothymidine (FLT) standard uptake value (SUV) between baseline and after one cycle of chemotherapy in patients categorized by RECIST 1.1 compu...

    John P. Crandall, Abdel K. Tahari, Rosalyn A. Juergens, Julie R. Brahmer, Charles M. Rudin, Giuseppe Esposito, Deepa S. Subramaniam, Michael V. Knopp, Nathan C. Hall, Prateek Gajwani, Jeffrey P. Leal, Martin A. Lodge, Joo H. O., Edward W. Gabrielson, Lalitha K. Shankar and Richard L. Wahl

    EJNMMI Research 2017 7:8

    Published on: 19 January 2017

  7. Original research

    Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

    In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regi...

    Carlos Velasco, Jesus Mateo, Arnoldo Santos, Adriana Mota-Cobian, Fernando Herranz, Juan Pellico, Ruben A. Mota, Samuel España and Jesus Ruiz-Cabello

    EJNMMI Research 2017 7:7

    Published on: 18 January 2017

  8. Original research

    Comparison of Tc-99m maraciclatide and Tc-99m sestamibi molecular breast imaging in patients with suspected breast cancer

    Molecular breast imaging (MBI) performed with 99mTc sestamibi has been shown to be a valuable technique for the detection of breast cancer. Alternative radiotracers such as 99mTc maraciclatide may offer improved ...

    Michael K. O’Connor, Melissa M. B. Morrow, Katie N. Hunt, Judy C. Boughey, Dietlind L. Wahner-Roedler, Amy Lynn Conners, Deborah J. Rhodes and Carrie B. Hruska

    EJNMMI Research 2017 7:5

    Published on: 14 January 2017

  9. Original research

    Patient-specific optimisation of administered activity and acquisition times for 18F-FDG PET imaging

    The purpose of this study is to identify a method for optimising the administered activity and acquisition time for 18F-FDG PET imaging, yielding images of consistent quality for patients with varying body sizes ...

    Fred Wickham, Helena McMeekin, Maria Burniston, Daniel McCool, Deborah Pencharz, Annah Skillen and Thomas Wagner

    EJNMMI Research 2017 7:3

    Published on: 13 January 2017

  10. Preliminary research

    Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients

    Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pre...

    Manon N. G. J. A. Braat, Hugo W. de Jong, Beatrijs A. Seinstra, Mike V. Scholten, Maurice A. A. J. van den Bosch and Marnix G. E. H. Lam

    EJNMMI Research 2017 7:2

    Published on: 5 January 2017

  11. Original research

    Three-minute SPECT/CT is sufficient for the assessment of bone metastasis as add-on to planar bone scintigraphy: prospective head-to-head comparison to 11-min SPECT/CT

    The aim of this study is to assess whether ultra-fast acquisition SPECT/CT (UF-SPECT/CT) can replace standard SPECT/CT (std-SPECT/CT) as “add-on” to whole-body bone scintigraphy (WB-BS) for the investigation o...

    Helle D. Zacho, José A. Biurrun Manresa, Ramune Aleksyniene, June A. Ejlersen, Joan Fledelius, Henrik Bertelsen and Lars J. Petersen

    EJNMMI Research 2017 7:1

    Published on: 5 January 2017

  12. Original research

    Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1

    177Lu-[DOTA0, Tyr3]-octreotate (177Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remissio...

    Johanna Dalmo, Johan Spetz, Mikael Montelius, Britta Langen, Yvonne Arvidsson, Henrik Johansson, Toshima Z. Parris, Khalil Helou, Bo Wängberg, Ola Nilsson, Maria Ljungberg and Eva Forssell-Aronsson

    EJNMMI Research 2017 7:6

    Published on: 5 January 2017

  13. Original research

    Yttrium-90 radioembolization for colorectal cancer liver metastases: a prospective cohort study on circulating angiogenic factors and treatment response

    Yttrium-90 radioembolization (90Y-RE) as a treatment for liver tumours induces radiation damage and hypoxia in liver tissue, which is also a trigger for systemic release of angiogenic factors, potentially stimula...

    C. E. N. M. Rosenbaum, A. F. van den Hoven, M. N. G. J. A. Braat, M. Koopman, M. G. E. H. Lam, B. A. Zonnenberg, H. M. Verkooijen and M. A. A. J. van den Bosch

    EJNMMI Research 2016 6:92

    Published on: 21 December 2016

  14. Original research

    Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging

    Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer ...

    Kirsi Mikkola, Cheng-Bin Yim, Paula Lehtiniemi, Saila Kauhanen, Miikka Tarkia, Tuula Tolvanen, Pirjo Nuutila and Olof Solin

    EJNMMI Research 2016 6:91

    Published on: 13 December 2016

  15. Original research

    Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft

    Sorafenib, an oral multikinase inhibitor, has anti-proliferative and anti-angiogenic activities and is therapeutically effective against renal cell carcinoma (RCC). Recently, we have evaluated the tumor respon...

    Naoyuki Ukon, Songji Zhao, Wenwen Yu, Yoichi Shimizu, Ken-ichi Nishijima, Naoki Kubo, Yoshimasa Kitagawa, Nagara Tamaki, Kei Higashikawa, Hironobu Yasui and Yuji Kuge

    EJNMMI Research 2016 6:90

    Published on: 12 December 2016

  16. Original research

    99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study

    Biologicals directed against tumour necrosis factor (TNF) have proven their efficacy in the treatment of spondyloarthritis and rheumatoid arthritis. We present a radiolabelling method for certolizumab pegol (C...

    Bieke Lambert, Philippe Carron, Yves D’Asseler, Klaus Bacher, Filip Van den Bosch, Dirk Elewaut, Gust Verbruggen, Rudi Beyaert, Caroline Dumolyn and Filip De Vos

    EJNMMI Research 2016 6:88

    Published on: 12 December 2016

  17. Original research

    Computational simulation of the predicted dosimetric impact of adjuvant yttrium-90 PET/CT-guided percutaneous ablation following radioembolization

    90Y PET/CT post-radioembolization imaging has demonstrated that the distribution of 90Y in a tumor can be non-uniform. Using computational modeling, we predicted the dosimetric impact ...

    Alexander S. Pasciak, Abigail Lin, Christos Georgiades, Laura K. Findeiss, Shannon Kauffman and Yong C. Bradley

    EJNMMI Research 2016 6:89

    Published on: 12 December 2016

  18. Original research

    Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers

    Accurate quantification in molecular imaging is essential to improve the assessment of novel drugs and compare the radiobiological effects of therapeutic agents prior to in-human studies. The aim of this study...

    Ana M. Denis-Bacelar, Sarah E. Cronin, Chiara Da Pieve, Rowena L. Paul, Sue A. Eccles, Terence J. Spinks, Carol Box, Adrian Hall, Jane K. Sosabowski, Gabriela Kramer-Marek and Glenn D. Flux

    EJNMMI Research 2016 6:85

    Published on: 25 November 2016

  19. Original Research

    The effect of isoflurane on 18F-FDG uptake in the rat brain: a fully conscious dynamic PET study using motion compensation

    In preclinical positron emission tomography (PET) studies an anaesthetic is used to ensure that the animal does not move during the scan. However, anaesthesia may have confounding effects on the drug or tracer...

    Matthew G. Spangler-Bickell, Bart de Laat, Roger Fulton, Guy Bormans and Johan Nuyts

    EJNMMI Research 2016 6:86

    Published on: 25 November 2016

  20. Original research

    Predictive factors of 18F-choline PET/CT positivity in patients with prostate cancer recurrence after radiation therapy: is the impact of PSA nadir underestimated?

    The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with 18F-choline (CH) PET/CT after external beam radiation therapy (EBRT).

    Alison C. Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly and Nicolas Aide

    EJNMMI Research 2016 6:84

    Published on: 21 November 2016

  21. Original research

    Improved safety and efficacy of 213Bi-DOTATATE-targeted alpha therapy of somatostatin receptor-expressing neuroendocrine tumors in mice pre-treated with l-lysine

    Targeted alpha therapy (TAT) offers advantages over current β-emitting conjugates for peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors. PRRT with 177Lu-DOTATATE or 90Y-DOTATOC has shown dose-...

    Ho Sze Chan, Mark W. Konijnenberg, Tamara Daniels, Monique Nysus, Mehran Makvandi, Erik de Blois, Wouter A. Breeman, Robert W. Atcher, Marion de Jong and Jeffrey P. Norenberg

    EJNMMI Research 2016 6:83

    Published on: 21 November 2016

  22. Original research

    Evaluation of 18F-fluorothymidine positron emission tomography ([18F]FLT-PET/CT) methodology in assessing early response to chemotherapy in patients with gastro-oesophageal cancer

    3’-Deoxy-3’-[18F]fluorothymidine ([18F]FLT) PET has limited utility in abdominal imaging due to high physiological hepatic uptake of a tracer. We evaluated [18F]FLT-PET/CT combined with a temporal-intensity infor...

    R. Sharma, P. Mapelli, G. B. Hanna, R. Goldin, D. Power, A. Al-Nahhas, S. Merchant, R. Ramaswami, A. Challapalli, T. Barwick and E. O. Aboagye

    EJNMMI Research 2016 6:81

    Published on: 16 November 2016

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