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  1. CD103 is an integrin specifically expressed on the surface of cancer-reactive T cells. The number of CD103+ T cells significantly increases during successful immunotherapy and might therefore be an attractive ...

    Authors: Xiaoyu Fan, Marta A. Ważyńska, Arjan Kol, Noemi Perujo Holland, Bruna Fernandes, Sander M. J. van Duijnhoven, Annechien Plat, Hans van Eenennaam, Philip H. Elsinga, Hans W. Nijman and Marco de Bruyn
    Citation: EJNMMI Research 2023 13:100
    Content type: Original research Published on:

  2. Targeting prostate-specific membrane antigen (PSMA) has been highly successful for imaging and treatment of prostate cancer. However, heterogeneity in immunohistochemistry indicates limitations in the effect o...

    Authors: Hui Wang, Marianne Remke, Thomas Horn, Kristina Schwamborn, Yiyao Chen, Katja Steiger, Wilko Weichert, Hans-Jürgen Wester, Margret Schottelius, Wolfgang A. Weber and Matthias Eiber
    Citation: EJNMMI Research 2023 13:99
    Content type: Original research Published on:

  3. Brain [18F]FDG PET is used clinically mainly in the presurgical evaluation for epilepsy surgery and in the differential diagnosis of neurodegenerative disorders. While scans are usually interpreted visually on an...

    Authors: Sameer Omer Jin, Inés Mérida, Ioannis Stavropoulos, Robert D. C. Elwes, Tanya Lam, Eric Guedj, Nadine Girard, Nicolas Costes and Alexander Hammers
    Citation: EJNMMI Research 2023 13:98
    Content type: Original research Published on:

  4. The need for arterial blood data in quantitative PET research limits the wider usability of this imaging method in clinical research settings. Image-derived input function (IDIF) approaches have been proposed ...

    Authors: Tommaso Volpi, Lucia Maccioni, Maria Colpo, Giulia Debiasi, Amedeo Capotosti, Tommaso Ciceri, Richard E. Carson, Christine DeLorenzo, Andreas Hahn, Gitte Moos Knudsen, Adriaan A. Lammertsma, Julie C. Price, Vesna Sossi, Guobao Wang, Paolo Zanotti-Fregonara, Alessandra Bertoldo…
    Citation: EJNMMI Research 2023 13:97
    Content type: Review Published on:

  5. Splenic switch-off (SSO) is a marker of adequate adenosine-induced vasodilatation on cardiac magnetic resonance perfusion imaging. We evaluate the feasibility of quantitative assessment of SSO in myocardial po...

    Authors: Satu Irene Inkinen, Eero Hippeläinen and Valtteri Uusitalo
    Citation: EJNMMI Research 2023 13:96
    Content type: Original research Published on:

  6. PSMA expression is influenced by hormonal status. We evaluated changes in PSA and whole-body 68Ga-PSMA-11 PET/CT (WB-PSMA PET) after initiation of androgen receptor signaling inhibitors (ARSi).

    Authors: Ida Sonni, Andrei Gafita, Lena M. Unterrainer, Rejah M. Alano, Stephanie Lira, John Shen, Alexandra Drakaki, Tristan Grogan, Matthew B. Rettig, Johannes Czernin and Jeremie Calais
    Citation: EJNMMI Research 2023 13:95
    Content type: Short communication Published on:

  7. Owing to the advances in diagnosis and therapy, survival or remission rates for lymphoma have improved prominently. Apart from the lymphoma- and chemotherapy-related somatic symptom burden, increasing attentio...

    Authors: Junyi Liu, Ming Tang, Dongling Zhu, Ge Ruan, Sijuan Zou, Zhaoting Cheng, Xiaohua Zhu and Yuankai Zhu
    Citation: EJNMMI Research 2023 13:94
    Content type: Original research Published on:

  8. Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggeste...

    Authors: Hayel Tuncel, Denise Visser, Tessa Timmers, Emma E. Wolters, Rik Ossenkoppele, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard and Sandeep S. V. Golla
    Citation: EJNMMI Research 2023 13:93
    Content type: Original research Published on:

  9. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma in adults. Standard treatment includes chemoimmunotherapy with R-CHOP or similar regimens. Despite treatment advancement...

    Authors: Fenglian Jing, Yunuan Liu, Xinming Zhao, Na Wang, Meng Dai, Xiaolin Chen, Zhaoqi Zhang, Jingmian Zhang, Jianfang Wang and Yingchen Wang
    Citation: EJNMMI Research 2023 13:92
    Content type: Original research Published on:

  10. The EANM Research Ltd. (EARL) guidelines give recommendations for harmonization of [18F]FDG PET-CT image acquisition and reconstruction, aiming to ensure reproducibility of quantitative data between PET scanners....

    Authors: Maurice C. Cox, Tijn Jurcka, Anne I. J. Arens, Maartje C. van Rijk, Johannes H. A. M. Kaanders and Sven van den Bosch
    Citation: EJNMMI Research 2023 13:91
    Content type: Original research Published on:

  11. After myocardial infarction, fibrosis and an ongoing dysregulated inflammatory response have been shown to lead to adverse cardiac remodeling. FDG PET is an imaging modality sensitive to inflammation as long a...

    Authors: Benjamin Wilk, Haris Smailovic, Rebecca Sullivan, Erik R. Sistermans, John Butler, Hannah Jago, Michael Kovacs, Gerald Wisenberg, Jonathan D. Thiessen and Frank S. Prato
    Citation: EJNMMI Research 2023 13:90
    Content type: Original research Published on:

  12. Vertebral compression fractures (VCFs) are common clinical problems that arise from various reasons. The differential diagnosis of benign and malignant VCFs is challenging. This study was designed to develop a...

    Authors: Xun Wang, Dandan Zhou, Yu Kong, Nan Cheng, Ming Gao, Guqing Zhang, Junli Ma, Yueqin Chen and Shuang Ge
    Citation: EJNMMI Research 2023 13:89
    Content type: Original research Published on:

  13. Convolutional neural networks (CNNs), applied to baseline [18F]-FDG PET/CT maximum intensity projections (MIPs), show potential for treatment outcome prediction in diffuse large B-cell lymphoma (DLBCL). The aim o...

    Authors: Maria C. Ferrández, Sandeep S. V. Golla, Jakoba J. Eertink, Bart M. de Vries, Sanne E. Wiegers, Gerben J. C. Zwezerijnen, Simone Pieplenbosch, Louise Schilder, Martijn W. Heymans, Josée M. Zijlstra and Ronald Boellaard
    Citation: EJNMMI Research 2023 13:88
    Content type: Original research Published on:

  14. Composite invasive and non-invasive data consistently demonstrate that resting myocardial blood flow (rMBF) in regions of known transmural myocardial scar (TMS) converge on a value of ~ 0.30 mL/min/g or lower....

    Authors: Robert M. Bober, Richard V. Milani, Sergey M. Kachur and Daniel P. Morin
    Citation: EJNMMI Research 2023 13:87
    Content type: Original research Published on:

  15. Kinetic modelling of dynamic PET typically requires knowledge of the arterial radiotracer concentration (arterial input function, AIF). Its accurate determination is very difficult in mice. AIF measurements in...

    Authors: Juela Cufe, Florian Gierse, Klaus P. Schäfers, Sven Hermann, Michael A. Schäfers, Philipp Backhaus and Florian Büther
    Citation: EJNMMI Research 2023 13:86
    Content type: Original research Published on:

  16. Recurrent myocardial infarction (RMI) portends an unfavorable outcome, which might be related to diminished hematopoietic-inflammatory activation. We aimed to investigate the hematopoietic-inflammatory activat...

    Authors: Yao Lu, Jingjing Meng, Mingkai Yun, Marcus Hacker, Xiang Li and Xiaoli Zhang
    Citation: EJNMMI Research 2023 13:85
    Content type: Original research Published on:

  18. In 2022, the American Food and Drug Administration and the European Medicines Agency approved [177Lu]Lu-PSMA-617 (PLUVICTO™, Novartis AG, Basel, Switzerland) for radionuclide therapy with prostate-specific membra...

    Authors: Jan Heilinger, Jasmin Weindler, Katrin Sabine Roth, Philipp Krapf, Klaus Schomäcker, Markus Dietlein, Alexander Drzezga and Carsten Kobe
    Citation: EJNMMI Research 2023 13:83
    Content type: Original research Published on:

  19. The neuropathological changes of early Alzheimer’s disease (AD) include neurodegenerative loss of noradrenaline neurons in the locus coeruleus with decreasing noradrenaline availability in their projection are...

    Authors: Takayuki Sakai, Saori Hattori, Aya Ogata, Takashi Yamada, Junichiro Abe, Hiroshi Ikenuma, Masanori Ichise, Masaaki Suzuki, Kengo Ito, Takashi Kato and Yasuyuki Kimura
    Citation: EJNMMI Research 2023 13:82
    Content type: Original research Published on:

  20. Radiolabeled-antibodies usually display non-specific liver accumulation that may impair image analysis and antibody biodistribution. Here, we investigated whether Fc silencing influenced antibody biodistributi...

    Authors: Tristan Mangeat, Matthieu Gracia, Alexandre Pichard, Sophie Poty, Pierre Martineau, Bruno Robert and Emmanuel Deshayes
    Citation: EJNMMI Research 2023 13:81
    Content type: Preliminary research Published on:

  21. The low throughout of small animal positron emission tomography (PET) images acquisitions represents a substantial limitation. The aims of this study were (i) to design a low-cost support for simultaneous dyna...

    Authors: Caroline Bouillot, Sébastien Daligault, Radu Bolbos, Nicolas Costes and Luc Zimmer
    Citation: EJNMMI Research 2023 13:80
    Content type: Original research Published on:

  22. Accurate analysis of quantitative PET data plays a crucial role in studying small, specific brain structures. The integration of PET and MRI through an integrated PET/MR system presents an opportunity to lever...

    Authors: Yi Shan, Shao-zhen Yan, Zhe Wang, Bi-xiao Cui, Hong-wei Yang, Jian-min Yuan, Ya-yan Yin, Feng Shi and Jie Lu
    Citation: EJNMMI Research 2023 13:79
    Content type: Original research Published on:

  23. Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments target...

    Authors: Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen and Lars Stegger
    Citation: EJNMMI Research 2023 13:78
    Content type: Original research Published on:

  24. Early detection of recurrent or progressive HCC remains the strongest prognostic factor for survival. Dual tracer PET/CT imaging with [11C]CH and [18F]FDG can further increase detection rates as both tracers enta...

    Authors: Emile B. Veenstra, Simeon J. S. Ruiter, Robbert J. de Haas, Koert P. de Jong, Paola A. Erba, Rudi A. J. O. Dierckx and Walter Noordzij
    Citation: EJNMMI Research 2023 13:77
    Content type: Original research Published on:

  26. Several software tools have been developed for gated PET imaging that use distinct algorithms to analyze tracer uptake, myocardial perfusion, and left ventricle volumes and function. Studies suggest that diffe...

    Authors: Mathias J. Zacherl, Agus Simenhandra, Magdalena Lindner, Peter Bartenstein, Andrei Todica, Guido Boening and Maximilian Fischer
    Citation: EJNMMI Research 2023 13:75
    Content type: Original research Published on:

  27. Atypical parkinsonism (AP) often presents with Parkinson’s symptoms but has a much worse long-term prognosis. The diagnosis is presently based on clinical criteria, but a cerebral positron emission tomography ...

    Authors: Naba Jawad Houssein, Alexander Cuculiza Henriksen, Anne-Mette Hejl and Lisbeth Marner
    Citation: EJNMMI Research 2023 13:74
    Content type: Original research Published on:

  28. In vivo monitoring of cell biodistribution using positron emission tomography (PET) provides a quantitative non-invasive method to further optimize cell therapies and related new developments in the field. Our...

    Authors: Ida Friberger, Joachim N. Nilsson, Li Lu, Jonathan Siikanen, Oscar Ardenfors, Stefan Milton, Erik Samén, Jeroen A. C. M. Goos, Mattias Carlsten, Staffan Holmin and Thuy A. Tran
    Citation: EJNMMI Research 2023 13:73
    Content type: Original research Published on:

  29. Chylothorax is a condition that can be challenging to diagnose due to its nonspecific clinical presentation. Several biochemical parameters of chylous pleural effusion have been identified as important indicat...

    Authors: Li Zhang, Xiaoyue Zhang, Zhe Wen, Guansheng Tong, Kun Hao, Yongkang Qiu and Lei Kang
    Citation: EJNMMI Research 2023 13:72
    Content type: Original research Published on:

  30. Behavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), hampering diagnostic distinction. Voxel-wi...

    Authors: Marie-Paule E. van Engelen, Sander C. J. Verfaillie, Annemieke Dols, Mardien L. Oudega, Ronald Boellaard, Sandeep S. V. Golla, Marijke den Hollander, Rik Ossenkoppele, Philip Scheltens, Bart N. M. van Berckel, Yolande A. L. Pijnenburg and Everard G. B. Vijverberg
    Citation: EJNMMI Research 2023 13:71
    Content type: Original research Published on:

  31. To investigate the use of dynamic radiomics features derived from dual-time-point (DTP-feature) [18F]FDG PET metabolic uptake rate Ki parametric maps to develop a predictive model for response to chemotherapy in ...

    Authors: Rezvan Samimi, Isaac Shiri, Yashar Ahmadyar, Jörg van den Hoff, Alireza Kamali-Asl, Alireza Rezaee, Fereshteh Yousefirizi, Parham Geramifar and Arman Rahmim
    Citation: EJNMMI Research 2023 13:70
    Content type: Original research Published on:

  32. Lenvatinib is widely used to treat unresectable and advanced thyroid carcinomas. We aimed to determine whether 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) performed 1 we...

    Authors: Satoshi Takeuchi, Kenji Hirata, Keiichi Magota, Shiro Watanabe, Rika Moku, Akihiko Shiiya, Jun Taguchi, Shin Ariga, Tomohiro Goda, Yoshihito Ohhara, Takurou Noguchi, Yasushi Shimizu, Ichiro Kinoshita, Rio Honma, Yasushi Tsuji, Akihiro Homma…
    Citation: EJNMMI Research 2023 13:69
    Content type: Original research Published on:

  33. For safe and effective holmium-166 (166Ho) liver radioembolization, dosimetry is crucial and requires accurate healthy liver definition. The current clinical standard relies on manual segmentation and registratio...

    Authors: Martina Stella, Rob van Rooij, Marnix G. E. H. Lam, Hugo W. A. M. de Jong and Arthur J. A. T. Braat
    Citation: EJNMMI Research 2023 13:68
    Content type: Original research Published on:

  34. CXCR3 is a chemokine receptor and is expressed in innate and adaptive immune cells. It promotes the recruitment of T-lymphocytes and other immune cells to the inflammatory site in response to the binding of co...

    Authors: Santosh R. Alluri, Yusuke Higashi, Ashley Berendzen, Laurel A. Grisanti, Lisa D. Watkinson, Kamlendra Singh, Timothy J. Hoffman, Terry Carmack, Elizabeth A. Devanny, Miles Tanner and Kun-Eek Kil
    Citation: EJNMMI Research 2023 13:67
    Content type: Original research Published on:

  35. This study aimed to retrospectively evaluate the feasibility of total-body 18F-FDG PET/CT ultrafast acquisition combined with a deep learning (DL) image filter in the diagnosis of colorectal cancers (CRCs).

    Authors: Entao Liu, Zejian Lyu, Yuelong Yang, Yang Lv, Yumo Zhao, Xiaochun Zhang, Taotao Sun, Lei Jiang and Zaiyi Liu
    Citation: EJNMMI Research 2023 13:66
    Content type: Original research Published on:

  36. Over the last years, several strategies have been reported to improve the metabolic stability of minigastrin analogs. However, currently applied compounds still reveal limited in vitro and in vivo stability. W...

    Authors: Nadine Holzleitner, Thomas Günther, Amira Daoud-Gadieh, Constantin Lapa and Hans-Jürgen Wester
    Citation: EJNMMI Research 2023 13:65
    Content type: Original research Published on:

  37. Non-regional lymph node (NRLN) metastases has shown increasing importance in the prognosis evaluation and clinical management of primary metastatic hormone-sensitive prostate cancer (mHSPC). Hence, this study ...

    Authors: Zhangdong Jiang, Junjie Fan, Chaosheng Gan, Xiaoxin Dong, Guoqiang Gao, Zhuonan Wang, Dalin He, Lei Li, XiaoYi Duan and Kaijie Wu
    Citation: EJNMMI Research 2023 13:64
    Content type: Original research Published on:

  38. Selective internal radiation therapy with 90Y radioembolization aims to selectively irradiate liver tumours by administering radioactive microspheres under the theragnostic assumption that the pre-therapy injecti...

    Authors: Mercedes Riveira-Martin, Azadeh Akhavanallaf, Zahra Mansouri, Nicola Bianchetto Wolf, Yazdan Salimi, Alexis Ricoeur, Ismini Mainta, Valentina Garibotto, Antonio López Medina and Habib Zaidi
    Citation: EJNMMI Research 2023 13:63
    Content type: Original research Published on:

  39. Penile cancer is characterized by an early lymphatic dissemination. In intermediate and high-risk primary tumors without palpable inguinal lymph nodes, there is a 6–30% risk of micro-metastatic disease. Invasi...

    Authors: Juanito Gebruers, Laura Elst, Marcella Baldewijns, Liesbeth De Wever, Koen Van Laere, Maarten Albersen and Karolien Goffin
    Citation: EJNMMI Research 2023 13:62
    Content type: Original research Published on:

  40. Butylscopolamine (or hyoscine butylbromide, trade name Buscopan®) is occasionally administered as a premedication to reduce non-specific FDG uptake in the gastrointestinal tract based on its antiperistaltic effec...

    Authors: Falk Gühne, Ferdinand Ndum, Philipp Seifert, Thomas Winkens, Robert Drescher and Martin Freesmeyer
    Citation: EJNMMI Research 2023 13:61
    Content type: Original research Published on:

  41. Folate intake might reduce [68Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this co...

    Authors: Hinke Siebinga, Jeroen J. M. A. Hendrikx, Alwin D. R. Huitema and Berlinda J. de Wit-van der Veen
    Citation: EJNMMI Research 2023 13:60
    Content type: Original research Published on:

  42. The development of diagnostic and therapeutic radiopharmaceuticals is an hot topic in nuclear medicine. Several radiolabeled antibodies are under development necessitating both biokinetic and dosimetry extrapo...

    Authors: Silvano Gnesin, Nicolas Chouin, Michel Cherel, Steven Mark Dunn, Niklaus Schaefer, Alain Faivre-Chauvet, John O. Prior and Judith Anna Delage
    Citation: EJNMMI Research 2023 13:59
    Content type: Original research Published on:

  43. Lymph node metastasis is an important prognostic factor in locally advanced cervical cancer (LACC). No imaging method can successfully detect all (micro)metastases. This may result in (lymph node) recurrence a...

    Authors: Judit A. Adam, Edwin Poel, Berthe L. F. van Eck-Smit, Constantijne H. Mom, Lukas J. A. Stalpers, Jaap Stoker and Shandra Bipat
    Citation: EJNMMI Research 2023 13:58
    Content type: Original research Published on:

  44. Dosimetry promises many advantages for radiopharmaceutical therapies but repeat post-therapy imaging for dosimetry can burden both patients and clinics. Recent applications of reduced time point imaging for ti...

    Authors: Avery B. Peterson, David M. Mirando and Yuni K. Dewaraja
    Citation: EJNMMI Research 2023 13:57
    Content type: Original research Published on:

  45. The gastrin-releasing peptide receptor (GRPr) is a molecular target for the visualization of prostate cancer. Bombesin (BN) analogs are short peptides with a high affinity for GRPr. RM2 is a bombesin-based ant...

    Authors: Yinwen Wang, Hongmei Yuan, Sufan Tang, Yang Liu, Ping Cai, Nan Liu, Yue Chen and Zhijun Zhou
    Citation: EJNMMI Research 2023 13:56
    Content type: Original research Published on:

  46. The lack of noninvasive methods for assessment of dysregulated inflammation as a major driver of fibrosis (i.e., inflammation-fibrosis axis) has been a major challenge to precision management of fibrotic lung ...

    Authors: Qin Zhu, Clayton E. Barnes, Philip Z. Mannes, Joseph D. Latoche, Kathryn E. Day, Jessie R. Nedrow, Enrico M. Novelli, Carolyn J. Anderson and Sina Tavakoli
    Citation: EJNMMI Research 2023 13:55
    Content type: Original research Published on:

  47. The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FD...

    Authors: Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante and Arturo Chiti
    Citation: EJNMMI Research 2023 13:54
    Content type: Short communication Published on:

  48. Fluorine-18-labeled SSAs have the potential to become the next-generation tracer in SSTR-imaging in neuroendocrine tumor (NET) patients given their logistical advantages over the current gold standard gallium-...

    Authors: Lennert Boeckxstaens, Elin Pauwels, Vincent Vandecaveye, Wies Deckers, Frederik Cleeren, Jeroen Dekervel, Timon Vandamme, Kim Serdons, Michel Koole, Guy Bormans, Annouschka Laenen, Paul M. Clement, Karen Geboes, Eric Van Cutsem, Kristiaan Nackaerts, Sigrid Stroobants…
    Citation: EJNMMI Research 2023 13:53
    Content type: Original research Published on:

  49. Stage I lung adenocarcinoma is a heterogeneous group. Previous studies have shown the prognostic evaluation value of PET/CT in this cohort; however, few studies focused on stage I invasive adenocarcinoma manif...

    Authors: Xuan Zheng, Jie Lin, Jiageng Xie, Jia Jiang, Junping Lan, Xiaowei Ji, Kun Tang, Xiangwu Zheng and Jinjin Liu
    Citation: EJNMMI Research 2023 13:52
    Content type: Original research Published on:

  50. Immune checkpoint inhibitors, including those against programmed cell death protein-1 (PD-1) or its ligand (PD-L1), are routinely used to treat non-small cell lung cancer (NSCLC). PD-L1 is a validated prognost...

    Authors: Daniel Johnathan Hughes, Gitasha Chand, Jessica Johnson, Damion Bailey, Kathryn Adamson, Vicky Goh and Gary J. R. Cook
    Citation: EJNMMI Research 2023 13:51
    Content type: Original research Published on:

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  • ISSN: 2191-219X (electronic)